AB0829 Body composition in spondyloarthritis: is there any impact on disease activity?

Background The relationship between obesity and inflammation is bidirectional. Thus, may influence clinical response to biological treatment. Objectives To investigate the association of body composition with disease activity in patients spondyloarthritis (SA). Methods This a cross-sectional study designed on diagnosed according ASAS 2009 classification. Bath ankylosing spondylitis index (BASDAI), score (ASDAS), functional (BASFI), metrology (BASMI) were assessed. Obesity was evaluated clinically by mass (BMI) waist circumference (WC). Total composition, total regional fat lean mass, android/gynoid ratio (A/G), (FMI), fat-free (FFMI) measured dual-energy X-ray absorptiometry (DXA) reported as absolute values. Blood samples collected determine C-reactive protein serum (CRP) levels for each patient. Socio-demographic data, comorbidities, physical activity, disease-related variables (duration, characteristics, drugs) also collected. Correlations regressions made SPSS.20. Results Forty-four SA participants (65.9% male) enrolled. Their mean age 39.82 ± 14.20 years ASDAS CRP 1.42 0.86. Patients under biologic disease-modifying antirheumatic drugs (bDMARDs) showed lower FMI (p = 0.011), percentage 0.008), gynoid 0.01). using CRP, FMI, FFMI, visceral adipose tissue (VAT), appendicular height, A/G not statistically significant. Nevertheless, positively correlated (r 0.352; p 0.019), 0.329, 0.029), android 0.323, 0.032). persisted after adjustment duration (ß 0.355, 95%IC [0.00003; 0.0003], 0.021). Conclusion Gynoid affected our patients. However, fat, skeletal muscle no significant activity. Disclosure Interests None declared